UniProt Accession

 SARA_STAAE;  A6QES8

Genbank Protein ID

 AP009351

Genbank Nucleotide ID

 BAF66860.1

Protein Name

 Transcriptional regulator SarA

Protein Synonyms/Alias

 

Gene Name

 sarA

Gene Synonyms/Alias

 NWMN_0588

Created Date

 3-June-2014

Organism

 Staphylococcus aureus (strain Newman)

NCBI Taxa ID

 426430

Phosphorylation

Reference

 [1]Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.
 Sun F,Ding Y,Ji Q,Liang Z,Deng X,Wong CC,Yi C,Zhang L,Xie S,Alvarez S,Hicks LM,Luo C,Jiang H,Lan L,He C
 Proc. Natl. Acad. Sci. U.S.A. 2012, Sep, 18;109(38):15461-6. [PMID:22927394]

Functional Description From UniProt

 FUNCTION: Global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner. In a strain- dependent manner plays a role in multidrug resistance mechanism Is required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. Acts as a transcriptional activator of the genes encoding, among others, for fibronectin binding proteins (fnbA and fnbB), hemolysins (hla, hld, hlgB and hlgC), serine proteases (splA, splB, splD and splF) and of the bap gene, which is essential for biofilm development in some strains. Negatively regulates the expression of the genes for protein A (spa), lipase (lip), thermonuclease (nuc), immunodominant staphylococcal antigen B (isaB), staphylococcal serine and cysteine proteases (sspA and sspB), staphostatin B (sspC), metalloprotease aureolysin (aur) and collagen adhesin (cna). Probably activates the development of biofilm by both enhancing the ica operon transcription and suppressing the transcription of either a protein involved in the turnover of PIA/PNAG or a repressor of its synthesis, whose expression would be sigma-B-dependent

Sequence Annotation From UniProt

 

Key Word From UniProt

 Activator; Completeproteome; Cytoplasm; DNA-binding; Metal-binding; Repressor; Transcription; Transcriptionregulation; Virulence

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0009405   P:pathogenesis IEA:UniProtKB-KW
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW

  IPR010166   Accessory_regulator_Staph.
  IPR011991   WHTH_DNA-bd_dom.