| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase PknA |
Protein Synonyms/Alias | |
Gene Name | pknA |
Gene Synonyms/Alias | MRA_0017 |
Created Date | 3-June-2014 |
Organism | Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) |
NCBI Taxa ID | 419947 |
Phosphorylation | Position | Peptide | Code | Type | References | | 174 | DAAPVTQTGMVMGTA | T | LTP | [1] | |
Reference | [1]Interdomain interaction reconstitutes the functionality of PknA, a eukaryotic type Ser/Thr kinase from Mycobacterium tuberculosis. Thakur M,Chaba R,Mondal AK,Chakraborti PK J. Biol. Chem. 2008, Mar, 21;283(12):8023-33. [ PMID:18199749] |
Functional Description From UniProt | FUNCTION: Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as FtsZ and MurD. Shows a strong preference for Thr versus Ser as the phosphoacceptor |
| TRANSMEM 340 360 Helical; (Potential) |
| ATP-binding; Cellmembrane; Completeproteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Serine/threonine-proteinkinase; Transferase; Transmembrane; Transmembranehelix |
Protein Sequence | MSPRVGVTLS GRYRLQRLIA TGGMGQVWEA VDNRLGRRVA VKVLKSEFSS DPEFIERFRA 60
EARTTAMLNH PGIASVHDYG ESQMNGEGRT AYLVMELVNG EPLNSVLKRT GRLSLRHALD 120
MLEQTGRALQ IAHAAGLVHR DVKPGNILIT PTGQVKITDF GIAKAVDAAP VTQTGMVMGT 180
AQYIAPEQAL GHDASPASDV YSLGVVGYEA VSGKRPFAGD GALTVAMKHI KEPPPPLPPD 240
LPPNVRELIE ITLVKNPAMR YRSGGPFADA VAAVRAGRRP PRPSQTPPPG RAAPAAIPSG 300
TTARVAANSA GRTAASRRSR PATGGHRPPR RTFSSGQRAL LWAAGVLGAL AIIIAVLLVI 360
KAPGDNSPQQ APTPTVTTTG NPPASNTGGT DASPRLNWTE RGETRHSGLQ SWVVPPTPHS 420
RASLARYEIA Q 431 |
| GO:0016021 C:integral component of membrane IEA:UniProtKB-KW GO:0005886 C:plasma membrane IEA:UniProtKB-SubCell GO:0005524 F:ATP binding IEA:UniProtKB-KW GO:0004674 F:protein serine/threonine kinase activity IEA:UniProtKB-KW |
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