※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA-splicing endonuclease
Protein Synonyms/Alias
 
Gene Name
 endA
Gene Synonyms/Alias
 SSO0439
Created Date
 3-June-2014
Organism
 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
NCBI Taxa ID
 273057
Phosphorylation
Position
Peptide
Code
Type
References
174 RKSEGIRYIMFKWVK Y HTP [1]
Reference
 [1]Change of carbon source causes dramatic effects in the phospho-proteome of the archaeon Sulfolobus solfataricus.
 Esser D,Pham TK,Reimann J,Albers SV,Siebers B,Wright PC
 J. Proteome Res. 2012, Oct, 5;11(10):4823-33. [PMID:22639831]
Functional Description From UniProt
 FUNCTION: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; Lyase; Referenceproteome; tRNAprocessing.
Protein Sequence
 MVKALLVGSK VLVPSIDESR YLYSNGFYGK PIGISKPKGP KDIVRPLELS LIESVYLTKK 60
 GLINVVDKNG DLLEYKKLYE YSAMKINKFE ILYKVYEDLR EKGFIVRSGV KYGADFAVYT 120
 LGPGLEHAPY VVIAVDIDEE ITPHELLSFG RVSHSTKKRL VLALVDRKSE GIRYIMFKWV 180
 KM 182
  GO:0003676   F:nucleic acid binding IEA:InterPro
  GO:0000213   F:tRNA-intron endonuclease activity IEA:UniProtKB-HAMAP
  GO:0006388   P:tRNA splicing, via endonucleolytic cleavage and ligation IEA:UniProtKB-HAMAP
  IPR011856   tRNA_endonuc-like_dom.
  IPR006677   tRNA_intron_Endonuc_cat-like.
  IPR006678   tRNA_intron_Endonuc_N.
  IPR006676   tRNA_splic.
  IPR016442   tRNA_splic_arch_short.
  PF01974   tRNA_int_endo.
  PF02778   tRNA_int_endo_N.